Endocrine Abstracts

During pregnancy, levels of pregnancy-related proteins and hormones such as progesterone (P4), estrogen, and glucocorticoids (GC) increase. Although the regulatory mechanisms of P4 production in the placenta are not completely understood, studies using mouse models have demonstrated that P4 induces immunosuppression using a GC receptor-dependent pathway, suggesting that both it has been suggested that steroid hormones have a similar effect. Understanding the orchestrated role ...